Clinical Assessment
LCG Bioscience has successfully undertaken a wide range of pharmacodynamic assessments as safety and efficacy end-points in clinical studies.
The following table is not exhaustive, but indicates some of the clinical evaluations currently available at LCG Bioscience.
| Gynaecology |
|---|
| Ultrasound evaluation of endometrial thickness |
| Ultrasound evaluation of follicular growth |
| Hysteroscopy |
| Endometrial biopsy |
| Cervical smear and cytological evaluation |
| Vaginal maturation index |
| Monitoring of menstrual cycle (hormonal/scan) |
| Pharmacological control of menstrual cycle |
| Induction of endometrial growth in postmenopausal women |
| Andrology |
|---|
| Computer aided semen analysis (CASA) |
| Acrosome reaction ionophore challenge |
| Cardiovascular |
|---|
| ECG 12 leads (resting and under physical stress) |
| Single-channel ECG monitoring |
| QTc dispersion analysis |
| 24hr Non-Invasive Blood Pressure (NIBP) monitoring |
| 24hr Holter monitoring |
| Bleeding time (Ivy method or Simplate) |
| CNS and neurology |
|---|
| Cognitive function testing |
| Mood evaluation (UWIST) |
| Heat-pain model for analgesia testing |
| Dermatology |
|---|
| Local tolerability (Draize scale) |
| Patch testing |
| Skin biopsy |
| Endocrinology (male) |
|---|
| Pharmacological control of testosterone levels in healthy males (using LHRH agonist) |
| Growth and metabolism |
|---|
| Cytochrome P450 phenotyping |
| Radioisotope ADME studies |